The pancreas is a spongy, tube-shaped organ about 6 inches long. The head of the pancreas is on the right side of the abdomen. It is connected to the duodenum, the upper end of the small intestine. The narrow end of the pancreas, called the tail, extends to the left side of the body.
Pancreatic cancer is one of the most serious of cancers. It develops when cancerous cells form in the tissues of your pancreas — a large organ that lies horizontally behind the lower part of your stomach. Your pancreas secretes enzymes that aid digestion and hormones that help regulate the metabolism of carbohydrates.
Pancreatic cancer is a malignant tumor of the pancreas. Each year about 33,000 individuals in the United States are diagnosed with this condition, and more than 60,000 in Europe. Depending on the extent of the tumor at the time of diagnosis, the prognosis is generally regarded as poor, with few victims still alive five years after diagnosis, and complete remission still extremely rare
Signs and Symptoms of Pancreatic Cancer
Loss of appetite and unintentional weight loss. Unintended weight loss is a common sign of pancreatic cancer. Weight loss occurs in most types of cancer because cancerous (malignant) cells deprive healthy cells of nutrients, and this is especially true in pancreatic cancer.
As the cancer grows and spreads, pain often develops in the upper abdomen and sometimes spreads to the back. Cancer of the pancreas can also cause nausea, loss of appetite, weight loss, and weakness.
Jaundice is caused by a buildup of bilirubin (a substance produced in the liver) that causes a yellowing of the skin and whites of the eyes. Jaundice may also cause brown urine and clay-colored stools. The symptoms of pancreatic cancer are generally vague and can easily be attributed to other less serious and more common conditions. This lack of specific symptoms explains the high number of people who have a more advanced stage of disease when pancreatic cancer is discovered.
Treatment for Pancreatic cancer
Radiation therapy uses high-energy X-rays to destroy cancer cells. You may receive radiation treatments before or after cancer surgery, often in combination with chemotherapy. Or, your doctor may recommend a combination of radiation and chemotherapy treatments when your cancer can't be treated surgically.
Surgery may be done to remove all or part of the pancreas. Sometimes it is necessary to remove a portion of the stomach, duodenum, and other nearby tissues. This operation is called a Whipple procedure. In cases where the cancer in the pancreas cannot be removed, the surgeon may be able to create a bypass around the common bile duct or the duodenum if either is blocked.
Endoscopic stent placement: A stent (flexible tube) is placed in the bile duct to drain the bile into the small intestine or outside the body as needed. This is done when the tumor is blocking the bile duct and there is a build up of bile to prevent further build up.
Chemotherapy drugs kill cancer cells but also damage some normal cells. Short-term side effects might include nausea and vomiting, loss of appetite, hair loss, and mouth sores. Because chemotherapy can damage the bone marrow, where new blood cells are made, blood cell counts might become low.
Pancreatic Cancer Causes, Diagnosis, Treatment and Prognosis
Pancreatic cancer begins in the tissues of your pancreas, a large organ that lies horizontally behind the lower part of the stomach. Pancreatic cancer occurs most commonly in men between the ages of 35 and 70, it is the fourth most common cause of cancer mortality (behind lung cancer, colorectal cancer and breast cancer). Pancreatic cancer is usually an adenocarcinoma and it usually arises from the pancreatic duct cells which make up the major part of the pancreas.
Cause of pancreatic cancer
Pancreatic cancer is caused by damage to genes, but it is not known exactly why this damage happens. Evidence suggests that it is linked to exposure to carcinogens such as; cigarettes, food high in fat and protein and food additives. Possible predisposing factors are chronic pancreatitis, diabetes mellitus and chronic alcohol abuse.
There is some evidence that people who don't eat many fresh vegetables and fruits are more at risk from pancreatic cancer. Being overweight may cause a small increase in the risk of pancreatic cancer. Some industrial chemicals called chlorinated hydrocarbon solvents have been linked to pancreatic cancer, although they are unlikely to be a major factor. Other chemicals and exposures that have been linked to an increased risk of pancreatic cancer in some studies include pesticides, radiation, nickel, chromium and iron.
The average age of onset of pancreatic cancer is between 70 to 80 but heavy smokers and heavy drinkers present with pancreatic cancer an average of seven to 10 years earlier than the rest of the population.
Signs and symptoms of pancreatic cancer
The most common are weight loss, abdominal or low back pain, jaundice and diarrhea. Other more general effects include; fever, skin lesions, depression, anxiety and a premonition of impending death. Ascites ( fluid retention in the abdomen ) can be a sign of pancreatic tumors.
Diagnosis
It is very difficult to diagnose pancreatic cancer as the pancreas is so deep within the body and symptoms vary depending on the exact location of the tumor in the pancreas and which cells or function of the pancreas is affected by the tumour or cancer. Pancreatic cancer typically spreads rapidly and is seldom detected in its early stages, which is a major reason why it is a leading cause of cancer death. Pancreatic cancer specialists believe that anyone over 50 who develops diabetes and has unexplained weight loss should be investigated for other pancreatic disease. Courvoisier sign defines the presence of jaundice and a painlessly distended gallbladder as strongly indicative of pancreatic cancer and may be used to distinguish pancreatic cancer from gallstones.
Treatment
Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on your age, overall health and personal preferences. The first goal of pancreatic cancer treatment is to eliminate the cancer, when possible. Pancreatic cancer is relatively resistant to medical treatment and the only potentially curative treatment is surgery. Radiation therapy for pancreatic cancer can palliate pain but does not affect the patients survival.
Gemcitabine was approved by the US FDA in 1998 after a clinical trial reported improvements in quality of life in patients with advanced pancreatic cancer. Management of pain and other symptoms is an important part of the treatment of advanced pancreatic cancer.
Prognosis
Pancreatic cancer often has a poor prognosis, even when diagnosed early and the median survival period from the time of diagnosis until demise is arguably the worst of any of the cancers. The best predictors of long term survival after surgery are a tumor diameter of less than 3 cm, no nodal involvement, negative resection margins, and diploid tumor DNA content.
Due to difficulties in diagnosis, the aggressive nature of pancreatic cancer and the limited systemic treatments available, the five-year survival rate for patients who have pancreatic adenocarcinoma is only about 5%.
Pancreatic cancer is one of the most serious of cancers. It develops when cancerous cells form in the tissues of your pancreas — a large organ that lies horizontally behind the lower part of your stomach. Your pancreas secretes enzymes that aid digestion and hormones that help regulate the metabolism of carbohydrates.
Pancreatic cancer is a malignant tumor of the pancreas. Each year about 33,000 individuals in the United States are diagnosed with this condition, and more than 60,000 in Europe. Depending on the extent of the tumor at the time of diagnosis, the prognosis is generally regarded as poor, with few victims still alive five years after diagnosis, and complete remission still extremely rare
Signs and Symptoms of Pancreatic Cancer
Loss of appetite and unintentional weight loss. Unintended weight loss is a common sign of pancreatic cancer. Weight loss occurs in most types of cancer because cancerous (malignant) cells deprive healthy cells of nutrients, and this is especially true in pancreatic cancer.
As the cancer grows and spreads, pain often develops in the upper abdomen and sometimes spreads to the back. Cancer of the pancreas can also cause nausea, loss of appetite, weight loss, and weakness.
Jaundice is caused by a buildup of bilirubin (a substance produced in the liver) that causes a yellowing of the skin and whites of the eyes. Jaundice may also cause brown urine and clay-colored stools. The symptoms of pancreatic cancer are generally vague and can easily be attributed to other less serious and more common conditions. This lack of specific symptoms explains the high number of people who have a more advanced stage of disease when pancreatic cancer is discovered.
Treatment for Pancreatic cancer
Radiation therapy uses high-energy X-rays to destroy cancer cells. You may receive radiation treatments before or after cancer surgery, often in combination with chemotherapy. Or, your doctor may recommend a combination of radiation and chemotherapy treatments when your cancer can't be treated surgically.
Surgery may be done to remove all or part of the pancreas. Sometimes it is necessary to remove a portion of the stomach, duodenum, and other nearby tissues. This operation is called a Whipple procedure. In cases where the cancer in the pancreas cannot be removed, the surgeon may be able to create a bypass around the common bile duct or the duodenum if either is blocked.
Endoscopic stent placement: A stent (flexible tube) is placed in the bile duct to drain the bile into the small intestine or outside the body as needed. This is done when the tumor is blocking the bile duct and there is a build up of bile to prevent further build up.
Chemotherapy drugs kill cancer cells but also damage some normal cells. Short-term side effects might include nausea and vomiting, loss of appetite, hair loss, and mouth sores. Because chemotherapy can damage the bone marrow, where new blood cells are made, blood cell counts might become low.
Pancreatic Cancer Causes, Diagnosis, Treatment and Prognosis
Pancreatic cancer begins in the tissues of your pancreas, a large organ that lies horizontally behind the lower part of the stomach. Pancreatic cancer occurs most commonly in men between the ages of 35 and 70, it is the fourth most common cause of cancer mortality (behind lung cancer, colorectal cancer and breast cancer). Pancreatic cancer is usually an adenocarcinoma and it usually arises from the pancreatic duct cells which make up the major part of the pancreas.
Cause of pancreatic cancer
Pancreatic cancer is caused by damage to genes, but it is not known exactly why this damage happens. Evidence suggests that it is linked to exposure to carcinogens such as; cigarettes, food high in fat and protein and food additives. Possible predisposing factors are chronic pancreatitis, diabetes mellitus and chronic alcohol abuse.
There is some evidence that people who don't eat many fresh vegetables and fruits are more at risk from pancreatic cancer. Being overweight may cause a small increase in the risk of pancreatic cancer. Some industrial chemicals called chlorinated hydrocarbon solvents have been linked to pancreatic cancer, although they are unlikely to be a major factor. Other chemicals and exposures that have been linked to an increased risk of pancreatic cancer in some studies include pesticides, radiation, nickel, chromium and iron.
The average age of onset of pancreatic cancer is between 70 to 80 but heavy smokers and heavy drinkers present with pancreatic cancer an average of seven to 10 years earlier than the rest of the population.
Signs and symptoms of pancreatic cancer
The most common are weight loss, abdominal or low back pain, jaundice and diarrhea. Other more general effects include; fever, skin lesions, depression, anxiety and a premonition of impending death. Ascites ( fluid retention in the abdomen ) can be a sign of pancreatic tumors.
Diagnosis
It is very difficult to diagnose pancreatic cancer as the pancreas is so deep within the body and symptoms vary depending on the exact location of the tumor in the pancreas and which cells or function of the pancreas is affected by the tumour or cancer. Pancreatic cancer typically spreads rapidly and is seldom detected in its early stages, which is a major reason why it is a leading cause of cancer death. Pancreatic cancer specialists believe that anyone over 50 who develops diabetes and has unexplained weight loss should be investigated for other pancreatic disease. Courvoisier sign defines the presence of jaundice and a painlessly distended gallbladder as strongly indicative of pancreatic cancer and may be used to distinguish pancreatic cancer from gallstones.
Treatment
Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on your age, overall health and personal preferences. The first goal of pancreatic cancer treatment is to eliminate the cancer, when possible. Pancreatic cancer is relatively resistant to medical treatment and the only potentially curative treatment is surgery. Radiation therapy for pancreatic cancer can palliate pain but does not affect the patients survival.
Gemcitabine was approved by the US FDA in 1998 after a clinical trial reported improvements in quality of life in patients with advanced pancreatic cancer. Management of pain and other symptoms is an important part of the treatment of advanced pancreatic cancer.
Prognosis
Pancreatic cancer often has a poor prognosis, even when diagnosed early and the median survival period from the time of diagnosis until demise is arguably the worst of any of the cancers. The best predictors of long term survival after surgery are a tumor diameter of less than 3 cm, no nodal involvement, negative resection margins, and diploid tumor DNA content.
Due to difficulties in diagnosis, the aggressive nature of pancreatic cancer and the limited systemic treatments available, the five-year survival rate for patients who have pancreatic adenocarcinoma is only about 5%.
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